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  • Optometry

    Can eye doctors see floaters issues without dilating eye (with special machine)?

    Does anybody else see this

    Was diagnosed with Episcleritis

    Is there any way of tracking eye pressure at home?

    Why do my eyes burn/sting every afternoon or night

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    The Legacy of the TTASAAN Report – Premature Conclusions and Forgotten Promises About SPECT Neuroimaging: A Review of Policy and Practice Part II

    Exosomes in the Field of Neuroscience: A Scientometric Study and Visualization Analysis

    Traditional Chinese Medicine Interventions in the Rehabilitation of Cognitive and Motor Function in Patients With Stroke: An Overview and Evidence Map

    Cerebral Blood Flow and Other Predictors of Responsiveness to Erenumab and Fremanezumab in Migraine—A Real-Life Study

    In vivo Illustration of Altered Dopaminergic and GABAergic Systems in Early Parkinson's Disease

    Potential Embolic Sources Differ in Patients With Embolic Stroke of Undetermined Source According to Age: A 15-Year Study

    A Single-Center Analysis of Sex Differences in Patients With Chronic Subdural Hematoma in China

    Factors Influencing the Outcome of Symptomatic Intracranial Artery Stenosis With Hemodynamic Impairment After Short and Long-Term Stent Placement

    Unusual Histopathological Findings in Mechanically Removed Stroke Thrombi – A Multicenter Experience

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    A future high myope: diagnosis with axial length

    Managing the non-myopic eye in unilateral myopia

    Predicting future myopia from axial length

    Why can I make my eyes sting and water on purpose?

    What Exactly is an Eye Chart?

    how bad is my vision?

    now i am starting to have anxiety and bring sad about my myopia

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In-Depth Characterization of Somatic and Orofacial Sensitive Dysfunctions and Interfering-Symptoms in a Relapsing-Remitting Experimental Autoimmune Encephalomyelitis Mouse Model

by Neuroptometry
January 17, 2022
in Research
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Among the many symptoms (motor, sensory, and cognitive) associated with multiple sclerosis (MS), chronic pain is a common disabling condition. In particular, neuropathic pain symptoms are very prevalent and debilitating, even in early stages of the disease. Unfortunately, chronic pain still lacks efficient therapeutic agents. Progress is needed (i) clinically by better characterizing pain symptoms in MS and understanding the underlying mechanisms, and (ii) preclinically by developing a more closely dedicated model to identify new therapeutic targets and evaluate new drugs. In this setting, new variants of experimental autoimmune encephalomyelitis (EAE) are currently developed in mice to exhibit less severe motor impairments, thereby avoiding confounding factors in assessing pain behaviors over the disease course. Among these, the optimized relapsing-remitting EAE (QuilA-EAE) mouse model, induced using myelin oligodendrocyte glycoprotein peptide fragment (35–55), pertussis toxin, and quillaja bark saponin, seems very promising. Our study sought (i) to better define sensitive dysfunctions and (ii) to extend behavioral characterization to interfering symptoms often associated with pain during MS, such as mood disturbances, fatigue, and cognitive impairment, in this optimized QuilA-EAE model. We made an in-depth characterization of this optimized QuilA-EAE model, describing for the first time somatic thermal hyperalgesia associated with mechanical and cold allodynia. Evaluation of orofacial pain sensitivity showed no mechanical or thermal allodynia. Detailed evaluation of motor behaviors highlighted slight defects in fine motor coordination in the QuilA-EAE mice but without impact on pain evaluation. Finally, no anxiety-related or cognitive impairment was observed during the peak of sensitive symptoms. Pharmacologically, as previously described, we found that pregabalin, a treatment commonly used in neuropathic pain patients, induced an analgesic effect on mechanical allodynia. In addition, we showed an anti-hyperalgesic thermal effect on this model. Our results demonstrate that this QuilA-EAE model is clearly of interest for studying pain symptom development and so could be used to identify and evaluate new therapeutic targets. The presence of interfering symptoms still needs to be further characterized.

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FEATURED POST

The Legacy of the TTASAAN Report – Premature Conclusions and Forgotten Promises About SPECT Neuroimaging: A Review of Policy and Practice Part II

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Traditional Chinese Medicine Interventions in the Rehabilitation of Cognitive and Motor Function in Patients With Stroke: An Overview and Evidence Map

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EDITOR PICK'S

The Legacy of the TTASAAN Report – Premature Conclusions and Forgotten Promises About SPECT Neuroimaging: A Review of Policy and Practice Part II

May 18, 2022

Exosomes in the Field of Neuroscience: A Scientometric Study and Visualization Analysis

May 18, 2022

Traditional Chinese Medicine Interventions in the Rehabilitation of Cognitive and Motor Function in Patients With Stroke: An Overview and Evidence Map

May 18, 2022

Cerebral Blood Flow and Other Predictors of Responsiveness to Erenumab and Fremanezumab in Migraine—A Real-Life Study

May 18, 2022

In vivo Illustration of Altered Dopaminergic and GABAergic Systems in Early Parkinson's Disease

May 18, 2022

Potential Embolic Sources Differ in Patients With Embolic Stroke of Undetermined Source According to Age: A 15-Year Study

May 18, 2022

A Single-Center Analysis of Sex Differences in Patients With Chronic Subdural Hematoma in China

May 18, 2022
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The Legacy of the TTASAAN Report – Premature Conclusions and Forgotten Promises About SPECT Neuroimaging: A Review of Policy and Practice Part II

May 18, 2022

Exosomes in the Field of Neuroscience: A Scientometric Study and Visualization Analysis

May 18, 2022

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