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    What is this test called?

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    Does $390 for plano lenses with anti-reflective coating make sense?

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    Consensus recommendations on therapeutic hypothermia after minimally invasive intracerebral hemorrhage evacuation from the hypothermia for intracerebral hemorrhage (HICH) working group

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    Corrigendum: Clinical 3-D gait assessment of patients with polyneuropathy associated with hereditary transthyretin amyloidosis

    Sudden sensorineural hearing loss as the initial symptom in patients with acoustic neuroma

    Simultaneous PET/MRI: The future gold standard for characterizing motor neuron disease—A clinico-radiological and neuroscientific perspective

    Neurological and psychological effects of long COVID in a young population: A cross-sectional study

    The association between blood MxA mRNA and long-term disease activity in early multiple sclerosis

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Home Research

Dynamic Evolution of the Glymphatic System at the Early Stages of Subarachnoid Hemorrhage

by Neuroptometry
July 3, 2022
in Research
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The early stages of subarachnoid hemorrhage (SAH) are extremely important for the progression and prognosis of this disease. The glymphatic system (GS) has positive implications for the nervous system due to its ability to clearance tau and amyloid-β (Aβ) protein. Previous studies have shown that GS dysfunction will appear after SAH. However, there is no systematic evaluation of the degree of damage and development process of GS function in the early stage after SAH. In this study, we evaluated the GS function and neurobehavioral in the sham, 6 h, 1, 3, and 7 days after SAH, respectively. Our results showed that the function of GS was severely attenuated in mice after SAH with a decreased polarity of Aquaporin-4 (AQP4), increased expression of AQP4, a linear correlation with the dystrophin-associated complex (DAC), the proliferation of reactive astrocytes, increased tau protein accumulation, and decreased neurological function. Collectively, these findings provide a comprehensive understanding of the functional changes of GS after SAH, provide references for subsequent scholars studying SAH, and suggest some potential mechanistic insight that affects AQP4 polarity and GS function.

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FEATURED POST

Consensus recommendations on therapeutic hypothermia after minimally invasive intracerebral hemorrhage evacuation from the hypothermia for intracerebral hemorrhage (HICH) working group

August 18, 2022

Editorial: Long term disability in neurological disease: A rehabilitation perspective

August 18, 2022

Effectiveness and safety of acupuncture for post-stroke spasticity: A systematic review and meta-analysis

August 18, 2022

Corrigendum: Clinical 3-D gait assessment of patients with polyneuropathy associated with hereditary transthyretin amyloidosis

August 18, 2022

EDITOR PICK'S

Consensus recommendations on therapeutic hypothermia after minimally invasive intracerebral hemorrhage evacuation from the hypothermia for intracerebral hemorrhage (HICH) working group

August 18, 2022

Editorial: Long term disability in neurological disease: A rehabilitation perspective

August 18, 2022

Effectiveness and safety of acupuncture for post-stroke spasticity: A systematic review and meta-analysis

August 18, 2022

Corrigendum: Clinical 3-D gait assessment of patients with polyneuropathy associated with hereditary transthyretin amyloidosis

August 18, 2022

Sudden sensorineural hearing loss as the initial symptom in patients with acoustic neuroma

August 18, 2022

Simultaneous PET/MRI: The future gold standard for characterizing motor neuron disease—A clinico-radiological and neuroscientific perspective

August 18, 2022

Neurological and psychological effects of long COVID in a young population: A cross-sectional study

August 18, 2022
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Consensus recommendations on therapeutic hypothermia after minimally invasive intracerebral hemorrhage evacuation from the hypothermia for intracerebral hemorrhage (HICH) working group

August 18, 2022

Editorial: Long term disability in neurological disease: A rehabilitation perspective

August 18, 2022

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